ESR 4: Michail Klontzas


Contact: Email, LinkedIn, ResearchGate, GoogleScholar
Project Title: Metabolism in mathematical modelling and bioprocess development for mesenchymal stem cell osteogenic differentiation in 2D and 3D cultures
Objectives: (i) Generate -omics datasets and use datasets generated by partners; (ii) Analyse data with multivariate/machine learning models; (iii) Derive an optimal differentiation strategy based on metabolomics results; (iv) Link metabolism of cell expansion (upstream) to the metabolism of the downstream differentiation (downstream); (v) Generate data to be used in a mathematical model describing osteogenic differentiation in collaboration with other partners
Host Organisation: Imperial College London
Supervisor: Prof. Athanasios Mantalaris & Dr. Nicki Panoskaltsis
Featured Scientist  (Sept/Oct2017)- Stem Cell Regenerative Medicine Network

Klontzas ME, Vernardis SI, Heliotis M, Tsiridis E, Mantalaris A, Metabolomics analysis of the osteogenic differentiation of umbilical cord blood mesenchymal stem cells reveals differential sensitivity to osteogenic agents, Stem Cells Dev 2017; Epub ahead of print; DOI: 10.1089/scd.2016.0315

Klontzas ME, Vassalou EE, Karantanas AH, Calcific tendinopathy of the shoulder with intraosseous extension: outcomes of ultrasound-guided percutaneous irrigation, Skeletal Radiol 2017; 46(2):201-8

Klontzas ME, Vassalou EE, Zibis AH, Karantanas AH Hydroxyapatite deposition disease around the hip: outcomes of CT-guided treatment, Diagn Interv Radiol 2016; 22(5):466-70

Klontzas ME, Kenanidis EI, MacFarlane RJ, Michail T, Potoupnis ME, Heliotis M, Mantalaris A, Tsiridis E, Investigational drugs for fracture healing: Preclinical & clinical data, Expert Opin Invest Drugs 2016; 25(5): 585-595

Vassalou EE, Klontzas ME, Kouvidis GK, Matalliotaki PI, Karantanas AH, Rotational knee laxity in anterior cruciate ligament deficiency: an additional MR imaging secondary sign, AJR Am J Roentgenol 2016; 206(1):151-4

Klontzas ME, Maris TG, Zibis AH, Karantanas AH, Normal magnetic resonance imaging anatomy of the anterolateral knee ligament with a T2/T1-Weighted 3-dimensional sequence: a feasibility study, Can Assoc Radiol J 2016;67(1):52-59

Klontzas ME, Zibis AH, Karantanas AH, Reply to “The half-moon sign of the femoral neck is non-specific for the diagnosis of osteoid osteoma”, AJR AM J Roentgenol 2016;W55-W56.

Kang Y, Georgiou AI, MacFarlane RJ, Klontzas ME, Heliotis M, Tsiridis E, Mantalaris A, Fibronectin stimulates the osteogenic differentiation of murine embryonic stem cells, J Tissue Eng Regen Med 2015; Epub ahead of print; doi: 10.1002/term.2090

Klontzas ME, Kenanidis EI, Heliotis M, Tsiridis E, Mantalaris A, Bone and cartilage regeneration with the use of umbilical cord mesenchymal stem cells, Expert Opin Biol Ther 2015;15(11):1541-52

Klontzas ME, Zibis AH, Karantanas AH, Osteoid osteoma of the femoral neck: use of the “half-moon” sign in MR imaging diagnosis, AJR Am J Roentgenol 2015; 205(2):353-7

Klontzas ME, Vassalou EE, Zibis AH, Bintoudi AS, Karantanas AH, MR imaging of transient osteoporosis of the hip: An update on 155 hip joints, Eur J Radiol 2015; 84(3)431-436

Klontzas ME, Hatzidakis A, Karantanas AH, Imaging findings in a case of stand up paddle surfer’s myelopathy, BJR case reports 2015; DOI:10.1259/bjrcr.20150004

Klontzas ME, Karantanas AH, Greater Trochanter Pain Syndrome: A descriptive MR imaging study, Eur J Radiol 2014; 83(10): 1850-1855.

Klontzas ME, Akoumianakis ID, Vagios I, Karantanas AH, MR findings of medial tibial crest friction, Eur J Radiol 2013;82(11):e703-e706