ESR 12: Osvaldo Kim
Project Title: Development of bi-level strain optimization algorithms and software tools
Objectives: (i) Development of bi-level strain optimization algorithms and respective computational tools, based on the use of dynamic models in the inner phenotype prediction layer; (ii) Identification of enzyme over/under expression or deletions leading to the maximization of the production of compounds of industrial interest; (iii) Metaheuristic optimization methods (e.g. Evolutionary Computation, Simulated Annealing) will be adapted and improved to address the underlying optimization tasks.
Host Organisation: SILICOLIFE Lda
Supervisor: Dr. Paulo Maia & Dr. Miguel Rocha (University of Minho)